研究業績（過去10年間のみ記載）

池内俊彦

• 学術論文
  1. Nakayama, H., Ueno, S., Ikeuchi, T. and Hatanaka, H. (2000) Regulation of nicotinic acetylcholine receptor subunit mRNA levels by NGF and cAMP in PC12 cells. Journal of Neurochemistry, 74, 1346-1354.
  2. Ishikawa, Y., Ikeuchi, T. and Hatanaka, H. (2000) Brain-derived neurotophic factor accelerates nitric oxide donor-induced apoptosis of cultured cortical neurons. Journal of Neurochemistry, 75, 494-502.
  3. Yamagishi, S., Yamada, M., Ishikawa, Y., Matsumoto, T., Ikeuchi, T. and Hatanaka, H. (2001) p38 Mitogen-activated protein kinase regulates low potassium-induced c-Jun phosphorylation and apoptosis in cultured cerebellar granule neurons. Journal of Biological Chemistry, 276, 5129-5133.
  4. Yamada, M., Suzuki, K., Mizutani, M., Asada, A., Motozaki, T., Ikeuchi, T., Koizumi, S. and Hatanaka, H. (2001) Analysis of tyrosine phosphorylation-dependent protein-protein interactions in TrkB-mediated intracellular signaling using modified yeast two-hybrid system. Journal of Biochemistry, 130, 157-165.
  5. Yamada, M., Tanabe, K., Wada, K., Shimoke, K., Ishikawa, Y., Ikeuchi, T., Koizumi, S. and Hatanaka, H. (2001) Differences in survival-promoting effects and intercellular signaling properties of BDNF and IGF-1 in cultured cerebral cortical neurons. Journal of Neurochemistry, 78, 940-951.
  6. Nakayama, H., Numakawa, T., Ikeuchi, T. and Hatanaka, H. (2001) Nicotine- induced phosphorylation of extracellular signal-regulated protein kinase and CREB in PC12h cells. Journal of Neurochemistry, 79, 489-498.
  7. Nakayama, H., Numakawa, T. and Ikeuchi, T. (2002) Nicotine-induced phosphorylation of Akt through epidermal growth factor receptor and Src in PC12h cells. Journal of Neurochemistry, 83, 1372-1379.
  8. Feng, Y., Kudo, M., Shimoke, K., Ikeuchi, T., Ebihara, Y. and Takahashi, M. (2002) Supprsssion of angiogenesis causes a significant delay of repair process in rat thromboembolic cerebral infarction. The Journal of Tokyo Medical University, 60, 489-500.
  9. Shimoke, K., Kudo, M. and Ikeuchi, T. (2003) MPTP-induced reactive oxygen species promote cell death through a gradual activation of caspase-3 without expression of GRP78/Bip as a preventive measure against ER stress in PC12 cells. Life Sciences, 73, 581-593.
  10. Yamagishi, S., Yamada, M., Koshimizu, H., Takai, S., Hatanaka, H., Takeda, K., Ichijo, H., Shimoke, K. and Ikeuchi, T. (2003) Apoptosis-signal regulating kinase-1 is involved in low potassium-induced activation of p38 mitogen-activated protein kinase and c-Jun in cultured cerebellar granule neurons. Journal of Biochemistry, 133, 719-724.
  11. Yamagishi, S., Matsumoto, T., Yokomaku, D., Hatanaka, H., Shimoke, K., Yamada, M. and Ikeuchi, T. (2003) Comparison of inhibitory effects of brain-derived neurotrophic factor and insulin-like growth factor-1 on low potassium-induced apoptosis and activation of p38 MAPK and c-Jun in cultured cerebellar granule neurons. Molecular Brain Research, 119, 184-191.
  12. Ishikawa, Y., Kusaka, E., Enokido, Y., Ikeuchi, T., and Hatanaka, H. (2003) Regulation of Bax translocation through phosphorylation at Ser-70 of Bcl-2 by MAP kinase in NO-induced neuronal apoptosis. Molecular Cellular Neuroscience, 24, 451-459.
  13. Shimoke, K., Amano, H., Kishi, S., Uchida, H., Kudo, M. and Ikeuchi, T. (2004) Nerve growth factor attenuates endoplasmic reticulum stress-mediated apoptosis via the suppression of caspase-12 activity in PC12 cells. Journal of Biochemistry, 135, 439-446.
  14. Utsumi, T., Shimoke, K., Kishi, S., Sasaya, H., Ikeuchi, T. and Nakayama, H. (2004) Protective effect of nicotine on tunicamycin-induced apoptosis of PC12 cells. Neuroscience Letters, 370, 244-247.
  15. Shimoke, K., Utsumi, T., Kishi, S., Nishimura, M., Sasaya, H., Kudo, M. and Ikeuchi, T. (2004) Prevention of endoplasmic reticulum stress-induced cell death by brain-derived neurotrophic factor in cultured cerebral cortical neurons. Brain Research, 1028, 105-111.
  16. Yamagishi, S., Matsumoto, T., Numakawa, T., Yokomaku, D., Adachi, N., Hatanaka, H., Yamada, M., Shimoke, K. and Ikeuchi, T. (2005) ERK1/2 are involved in low potassium-induced apoptotic signaling downstreem of ASK1-p38 MAPK pathway in cultured cerebellar granule neurons. Brain Research, 1038, 223-230.
  17. Shimoke, K., Kishi, S., Utsumi, T., Shimamura, Y., Sasaya, H., Oikawa, T., Uesato, S. and Ikeuchi, T. (2005) NGF-induced phosphatidylinositol 3-kinase signaling pathway prevents thapsigargin-triggered ER stress-mediated apoptosis in PC12 cells. Neuroscience Letters, 389, 124-128.
  18. Oikawa, T., Yamamoto, N., Shimoke, K., Uesato, S., Ikeuchi, T. and Fujioka, T. (2005) Purification, characterization, and overexpression of psychrophilic and thermolabile malate dehydrogenase of a novel antarctic psychrotorelant, Flavobacterium frigidimaris KUC-1. Bioscience, Biotechnology, and Biochemistry, 69, 2146-2154.
  19. Nakayama, H., Shimoke, K., Isosaki, M., Satoh, H., Yoshimizu, M. and Ikeuchi, T. (2006) Subtypes of neuronal nicotinic acetylcholine receptors involved in nicotine-induced phosphorylation of extracellular signal-regulated protein kinases in PC12h cells. Neuroscience Letters, 392, 101-104.
  20. Nagaoka, Y., Maeda, T., Kawai, Y., Nakashima, D., Oikawa, T., Shimoke, K., Ikeuchi, T., Kuwajima, H.,and Uesato, S. (2006) Synthesis and cancer antiproliferative activity of new histone deacetylase inhibitors: hydrophilic hydroxamates and 2-aminobenzamide-containing derivatives. European Journal of Medical Chemistry, 41, 697-708.
  21. Shimoke, K., Kudo, M. and Ikeuchi, T. (2007) Opposing mechanism of extracellular signal-regulated kinases on hydrogen peroxide-induced apoptosis in PC12 cells. The Journal of Tokyo Medical University, 65, 283-289.
  22. Kusunoki, T., Shimoke, K., Komatsubara, S., Kishi, S. and Ikeuchi, T. (2008) p-Nonylphenol induces endoplasmic reticulum stress-mediated apoptosis in neuronally differentiated PC12 cells. Neuroscience Letters, 431, 256-261.
  23. Sasaya, H., Utsumi, T., Shimoke, K., Nakayama, H., Matsumura, Y., Fukunaga, K. and Ikeuchi, T. (2008) Nicotine suppresses tunicamycin-induced, but not thapsigargin-induced, expression of GRP78 during ER stress-mediated apoptosis in PC12 cells. Journal of Biochemistry, 144, 251-257.
  24. Nakayama, H., Hamada, M., Fujikake, N., Nagai, Y., Zhao, J., Hatano, O., Shimoke, K., Isosaki, M., Yoshizumi, M. and Ikeuchi, T. (2008) ER stress is the initial response to polyglutamine toxicity in PC12 cells. Biochemical and Biophysical Research Communications, 377, 550-555.
  25. Shimoke, K., Yamazaki, I., Matsuki, Y., Ikeuchi, T. and Kudo, M. (2009) Caspase-3 activation and lipid peroxidation are important for apoptotic cell death in cerebral infarction. The Journal of Tokyo Medical University, 67, 15-21.
  26. Kishi, S., Shimoke, K., Nakatani, Y., Shimada, T., Okumura, N., Nagai, K., Shin-ya, K. and Ikeuchi, T. (2010) Nerve growth factor attenuates 2-deoxy-D-glucose-triggered endoplasmic reticulum stress-mediated apoptosis via enhanced expression of GRP78. Neuroscience Research, 66, 14-21.
  27. Maruoka, H., Sasaya, H., Shimamura, Y., Nakatani, Y., Shimoke, K. and Ikeuchi, T. (2010) Dibutyryl-cAMP up-regulates nur77 expression via histone modification during neurite outgrowth in PC12 cells. Journal of Biochemistry, 148, 93-101.
• 国際会議論文
  1. Ishikawa, Y., Ikeuchi, T. and Hatanaka, H. (2000) BDNF accelerates NO donor-induced apoptosis and Bcl-2 phosphorylation in cultured cortical neurons. Society for Neuroscience Abstracts 26, 1873.
  2. Ishikawa, Y., Kusaka, E., Ikeuchi, T. and Hatanaka, H. (2001) Evidence of BCL-2 phosphorylation and BAX translocation during NO-induced apoptosis. Society for Neuroscience Abstracts 27, 109.19.
  3. Yamagishi, S., Yamada, M., Ishikawa, Y., Matsumoto, T., Ikeuchi, T. and Hatanaka, H. (2001) Role of phosphatidylinositol 3-kinase and p38 mitogen-activated protein kinase in low potassium-induced apoptosis of cultured cerebellar granule neurons. Society for Neuroscience Abstracts 27, 695.7.
  4. Shimoke, K., Amano, H., Nishimura, M., Utsumi, T., Kuromi, Y. and Ikeuchi, T. (2003) NGF-mediated suppression of caspase-12 activation and apoptosis induced by ER stress in PC12 cells. Society for Neuroscience Abstracts 29, 709.17.
  5. Shimoke, K., Utsumi, T., Kishi, S., Sasaya, H. and Ikeuchi, T. (2004) Prevention of ER stress-induced cell death by BDNF in cultured cerebral cortical neurons. Society for Neuroscience Abstracts 30, 944.8.
  6. Shimoke, K., Yamamoto, Y., Kishi, S., Sasaya, H., Utsumi, T., Shimamura, Y., Shin-ya, K. and Ikeuchi, T. (2005) NGF prevents 2-deoxy-D-glucose-induced apoptosis in PC12 cells. Society for Neuroscience Abstracts 31, 337.8.
  7. Kishi, S., Shimoke, K., Sasaya, H., Shin-ya, K. and Ikeuchi, T. (2006) Nerve growth factor prevents ER stress-induced apoptosis in PC12 cells. IUBMB International Congress of Biochemistry and Molecular Biology Abstracts 20, 446.
  8. Hamada, M., Nakayama, H., Kishi, S., Nagai, Y., Shimoke, K. and Ikeuchi, T. (2006) Molecular mechanism of polyglutamine-expanded YFP-mediated ER stress in PC12 cell. IUBMB International Congress of Biochemistry and Molecular Biology Abstracts 20, 446.
  9. Nakayama, H., Utsumi, T., Shimoke, K., Sasaya, H., Shimamura, Y. and Ikeuchi, T. (2006) Nicotine protects tunicamycin-induced ER stress-mediated apoptosis in PC12 cells. IUBMB International Congress of Biochemistry and Molecular Biology Abstracts 20, 450.
  10. Shimoke, K., Komatsubara, S., Kishi, S., Hamade, M., Sasaya, H., Fujita, Y., and Ikeuchi, T. (2007) Involvement of up-regulated Bim expression in tunicamycin-induced ER stress-mediated apoptosis of PC12 cells. Society for Neuroscience Abstracts 33, 701.5.
  11. Shimoke, K., Kishi, S., Shimada T., Fujita, Y., Okumura, N. and Ikeuchi, T. (2008) Hyperinduction of GRP78 expression by NGF-TrkA signaling promotes cell survival during ER stress-mediated apoptosis of PC12 cell. Society for Neuroscience Abstracts 34, 355.9/BB4.
  12. Shimoke, K., Shimada, T., Kishi, S., Irifune, H., Nakatani, Y., Sasaya, H. and Ikeuchi, T. (2009) Nerve growth factor prevents ER stress-induced apoptosis via down-regulation of PUMA expression in PC12 cells. 17th ECDO Euroconference on Apoptosis Abstracts 28.
  13. Shimoke, K., Nakatani Y., Kishi, S., Shimada, T., Irifune, H., Sasaya, H. and Ikeuchi, T. (2009) Nerve growth factor enhances GRP78 expression only under the condition of ER stress in PC12 cells. Society for Neuroscience Abstracts 35, 153.7/M5.
• 学会発表

  2000-2006　22編あり

  1. 石川保幸, 池内俊彦, 畠中寛 NOによる神経細胞死におけるBDNFの細胞死促進にはリン酸化Bcl-２が関与している 第４３回日本神経化学会大会抄録集，39-3，351 2000
  2. 日下永子, 石川保幸, 池内俊彦, 畠中寛 脳及び胸腺に特異的に発現するp３８MAPKαの新規スプライス産物の同定と解析 第４３回日本神経化学会大会抄録集，39-3，379 2000
  3. 山田雅司, 鈴木健二, 小泉信一, 荒木敏行, 大西浩史, 佐野慎一郎, 池内俊彦, 畠中寛 脳由来神経栄養因子（BDNF）による細胞内シグナル伝達におけるチロシンリン酸化依存的蛋白質-蛋白質相互作用-酵母Two and half-hybrid系を用いた解析- 第７３回日本生化学会大会発表抄録集，72-8，984 2000
  4. 石川保幸, 日下永子, 池内俊彦, 畠中寛 NO誘導性神経細胞死におけるBcl‐2のリン酸化とBaxトランスロケーション 第44回日本神経化学会大会抄録集,　40‐2, 277 2001
  5. 日下永子, 石川保幸, 池内俊彦, 畠中寛 p38αの新規スプライス産物, p38α2は細胞死を誘導する 第44回日本神経化学会大会抄録集,　40‐2,279 2001
  6. 下家浩二, 岸宗一郎, 天野恭志, 伊藤博公, 内田仁司, 工藤玄恵, 池内俊彦 PC12細胞を用いたNGFによる小胞体ストレス抑制機構の解析, 第７５回日本生化学会発表抄録集、2002
  7. 天野恭志、下家浩二、伊藤博公、工藤玄恵、池内俊彦 NGFによる小胞体ストレス抑制機構、第25回日本分子生物学会抄録集、2002
  8. 楠高志、岸宗一郎、内田仁司、下家浩二、池内俊彦 分化PC12細胞を用いたp-Nonylphenolによる細胞死とNGFによる抑制機構の解析、第25回日本分子生物学会抄録集、2002
  9. Shimoke, K., Amano, H., Nishimura, M., Utsumi, T., Kuromi, Y., Kudo, M.and Ikeuchi, T. NGF-mediated suppression of caspase-12 activation and apoptosisinduced by ER stress in PC12 cells. 第７６回日本生化学会発表抄録集, 75-8,854 2003
  10. Shimoke, K., Nakayama, H., Kishi, S., Uchida, H. and Ikeuchi, T. Protective effect of nicotine on tunicamycin-induced apoptosis of PC12 cells. 第７６回日本生化学会発表抄録集, 75-8, 981 2003
  11. 西村学, 内海孝宏, 岸宗一郎, 内田仁司, 下家浩二, 池内俊彦 PC12細胞を用いたTauroursodeoxycholic acidによるTunicamycin誘導小胞体ストレス抑制機構の解析 第２６回日本分子生物学会年会抄録集, 1020 2003
  12. 岡本直樹, 内海孝宏, 黒見靖, 笹谷晴恵, 下家浩二, 池内俊彦 PC12細胞を用いた各種内分泌攪乱物質による細胞死誘導とNGFによる細胞死抑制機構の解析 第２６回日本分子生物学会年会抄録集, 1021 2003
  13. 中山均, 内海孝宏, 下家浩二, 池内俊彦 PC12細胞のツニカマイシン誘導アポトーシスに対するニコチン受容体を介した保護作用 第７７回日本薬理学会年会抄録集, 2004
  14. Shimoke, K., Utsumi, T., Kishi, S., Nishimura, M. and Ikeuchi, T. BDNF prevents ER stress-induced cell death in cultured cerebral cortical neurons. 第７７回日本生化学会発表抄録集, 76, 865 2004
  15. Sasaya, H., Kishi, S., Uchida, H., Shimoke, K. and Ikeuchi, T. Identification and characterization of signaling proteins which bind to the intracellular region of TrkA receptor using yeast two-hybrid system. 第７７回日本生化学会発表抄録集, 76, 865 2004
  16. 酒井祥太, 西村学, 岸宗一郎, 山本優子, 大西紀陽久, 笹谷晴恵, 下家浩二, 池内俊彦PC12細胞を用いた内分泌攪乱物質による小胞体ストレス誘導型細胞死とNGFによる細胞死抑制機構の解析 第２７回日本分子生物学会年会抄録集, 962 2004
  17. Nakayama, H., Shimoke, K., Nagai, Y., Isozaki, M., Satoh, H., Yoshizumi, M. and Ikeuchi, T. Relationship of polyglutamine-expanded GFP expression to ER stress in PC12 cells. 第４８回日本神経化学会抄録集, 192 2005
  18. Shimoke, K., Yamamoto, Y., Kishi, S., Sasaya, H., Utsumi, T., Shimamura, Y., Shin-ya, K. and Ikeuchi, T. NGF prevents 2-deoxy-D-glucose-induced apoptosis via PI3-K signaling pathway in PC12 cells. 第４８回日本神経化学会抄録集, 227 2005
  19. Yamamoto, Y., Shimoke, K., Kishi, S., Utsumi, T., Shin-ya, K. and Ikeuchi, T. Protective effect of NGF on 2-deoxy-D-glucose-induced apoptosis via PI3-K signaling pathway in PC12 cells. 第７８回日本生化学会発表抄録集, 77, 991 2005
  20. Shimamura, Y., Onishi, K., Maruoka, H., Sasaya, H., Maeda, D., Uesato, S., Shimoke, K. and Ikeuchi, T. Neurite outgrowth is induced by inhibitors of histone deacetylase in PC12 cells. 第７８回日本生化学会発表抄録集, 77, 991 2005
  21. Maruoka, H., Shimamura, Y., Sasaya, H., Kishi, S., Shimoke, K. and Ikeuchi, T. Epigenetic regulation of gene expression during neurite outgrowth by cAMP in PC12 cells. 第２８回日本分子生物学会年会抄録集, 218 2005
  22. Nakayama, H., Shimoke, K., Nagai, Y., Isozaki, M., Satoh, H., Yoshizumi, M. and Ikeuchi, T. Comparison of polyglutamine- , tunicamycin- and thapsigargin-induced ER stresses in PC12 cells. 第７９回日本薬理学会年会抄録集, 2006
  23. Shimoke, K., Kishi, S., Hamada, M., Sasaya, H., Fujita, Y. and Ikeuchi, T. (2007) Importance of up-regulated Bim expression during tunicamycin-induced ER stress-mediated apoptosis in PC12 cells. Bulletin of Japanese Society for Neurochemistry 46, 526.
  24. Nakayama, H., Hamada, M., Zhao, J., Shimoke, K., Isozaki, M., Satoh, H., Yoshizumi, M. and Ikeuchi, T. (2007) Effects of prorteasome inhibitors on tunicamycin-, thapsigargin-, and polyglutamine-induced ER stress and cell death in PC12 cells. Bulletin of Japanese Society for Neurochemistry 46, 527.
  25. Ando, K., Shimada, T., Kishi, S., Shimoke, K. and Ikeuchi, T. (2007) Analysis of endocrine disrupting chemical-induced ER stress-mediated apoptosis in PC12 cells. Congress of Biochemistry and Molecular Biology 2007 Abstracts 265.
  26. Kishi, S., Hamada, M., Fujita, Y., Shimoke, K., Shin-ya, K. and Ikeuchi, T. (2007) Nerve growth factor attenuates 2-deoxyglucose-triggered endoplasmic reticulum-mediated apoptosis via up-regulation of GRP78 expression. Congress of Biochemistry and Molecular Biology 2007 Abstracts 266.
  27. Sasaya, H., Utsumi, T., Shimoke, K.,Nakayama, H. and Ikeuchi, T. (2007) Nicotine suppresses tunicamycin-induced, but not thapsigargin-induced, expression of GRP78 during ER stress-mediated apoptosis in PC12 cells. Congress of Biochemistry and Molecular Biology 2007 Abstracts 266.
  28. Hamada, M., Shimoke, K., Kishi, S., Nagai, Y. and Ikeuchi, T. (2007) Polyglutamine-expanded protein-induced ER stress-mediated apoptosis and its suppression by NGF. Congress of Biochemistry and Molecular Biology 2007 Abstracts 445.
  29. Kishi, S., Shimoke, K., Okumura, N., Shimada, T., Fujita, Y., Nagai, K., Shin-ya, K. and Ikeuchi, T. (2008) Nerve growth factor attenuates 2-deoxyglucose-triggered endoplasmic reticulum-mediated apoptosis via enhanced induction of GRP78 expression. Bulletin of Japanese Society for Neurochemistry 47, 155.
  30. Sasaya, H., Shimoke, K., Kishi, S., Fijita, Y., Shimada, T., Nakayama, H. and Ikeuchi, T. (2008) Nicotine suppresses tunicamycin-induced expression during ER stress-mediated apoptosis via preventing a common step upstream of Ire1-XBP1 and ATF6 pathways in PC12 cells. Congress of Biochemistry and Molecular Biology 2008 Abstracts 238.
  31. Shimoke, K., Nakatani Y., Kishi, S., Shimada, T., Irifune, H., Sasaya, H. and Ikeuchi, T. (2009) Nerve growth factor promotes GRP78 expression only under the condition of ER stress. Bulletin of Japanese Society for Neurochemistry 48, 207.
  32. Nakatani, Y., Kishi, S., Shimoke, K., Shimada, T., Irifune, H., Sasaya, H. and Ikeuchi, T. (2009) Analysis of GRP78 promoter region involved in NGF-induced up-regulation during suppression of ER stress-mediated apoptosis in PC12 cells. Seikagaku 81, 3P-516.
  33. Shimada, T., Shimoke, K., Kishi, S., Irifune, H., Nakatani Y., Sasaya, H. and Ikeuchi, T. (2009) BAX oligomerization promotes ER stress-mediated apoptosis and nerve growth factor prevents it in PC12 cells. Japanese Society for Molecular Biology Abstracts 32, 2P-528.
• 総説・解説・紀要・その他

  1997-1999　3編あり

  1. T. Ikeuchi, H. Hatanaka Signaling pathways by which neurotophic factors prevent apoptosis in cultured cerebellar granule neurons. Recent Res. Devel. Neurochem., 3, 27-37 2000
  2. T. Ikeuchi, K. Shimoke Signal transduction mechanisms in neuronal cells: apoptosis-inducing and -preventing mechanisms. Proceedings of the Symposium of High Technology in Kansai University, 7, 2003
  3. K. Shimoke, T. Ikeuchi Endoplasmic reticulum stress-mediated apoptosis and its prevention by neurotrophic factors. Proceedings of the Symposium of High Technology in Kansai University 9, 115-123 2005
  4. K. Shimoke, T. Ikeuchi Endoplasmic reticulum stress-induced apoptosis and its prevention by neurotrophins. New Trends in Brain Research, 61-74 2006
  5. Ikeuchi, T. and Shimoke, K. (2007) Prevention of endoplasmic reticulum stress and its induced apoptosis by nicotine and neurotrophins. Proceedings of the Symposium of High Technology in Kansai University 11, 109-116.
  6. Shimoke, K. and Ikeuchi, T. (2007) Endoplasmic reticulum stress-induced apoptosis and its preventive mechanism: Possible therapeutic strategy against neurodegenerative disorders. Engineering and Technolopgy, 14, 39-43.
  7. Ikeuchi, T. and Shimoke, K. (2008) Apoptosis inducing chemicals in the environment. Engineering and Technolopgy, 15, 69-76.
  8. Ikeuchi, T., Tsuchido, T. and Yoshida, M. (2009) Action mechanism, environmental distribution and protection technology of apoptosis inducing chemicals in the environment. Proceedings of the Symposium of High Technology in Kansai University 13, 375-380.

下家浩二

• 学術論文
  1. K. Shimoke, and H. Chiba: Nerve growth factor prevents 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced cell death via the Akt pathway by suppressing caspase-3-like activity using PC12 cells: relevance to therapeutical application for Parkinson's disease. J. Neurosci. Res. 63(5), 402-409, (2001).
  2. M. Yamada, K. Tanabe, K. Wada, K. Shimoke, Y. Ishikawa, T. Ikeuchi,S. Koizumi, and H. Hatanaka: Differences in survival-promoting effects and intracellular signaling properties of BDNF and IGF-1 in cultured cerebral cortical neurons. J. Neurochem. 78(5), 940-951. (2001).
  3. K. Shimoke, M. Kudo: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine has a transient proliferative effect on PC12 cells and nerve growth factor additively promotes this effect: possible involvement of distinct mechanismsof activation of MAP kinase family proteins, Dev. Brain Res. 133 (2), 105-114,(2002).
  4. Feng, Y., Kudo, M., Shimoke, K., Ikeuchi, T., Ebihara, Y., and Takasaki,M.: Suppression of angiogenesis causes a significant delay of repair process in rat thoromboembolic cerebral infarction. J. Tokyo Med. Univ. 60(6),489-500, (2003)
  5. Shimoke, K., Kudo, M.,and Ikeuchi, T.: MPTP-induced reactive oxygen species promote cell death through a gradual activation of caspase-3 without expression of GRP78/Bip as a preventive measure against ER stress in PC12 cells. Life Sciences, in press (2003)
  6. Yamagishi S, Matsumoto T, Yokomaku D, Hatanaka H, Shimoke K, Yamada M, Ikeuchi T. Comparison of inhibitory effects of brain-derived neurotrophic factor and insulin-like growth factor on low potassium-induced apoptosis and activation of p38 MAPK and c-Jun in cultured cerebellar granule neurons. Mol Brain Res. 119(2):184-91, (2003)
  7. Shimoke, K., Amano, H., Kishi, S., Uchida, H., Kudo, M., and Ikeuchi, T. Nerve growth factor attenuates endoplasmic reticulum stress-mediated apoptosis via suppression of caspase-12 activity. J. Biochem. 135, 439-446, (2004)
  8. Utsumi, T., Shimoke, K., Kishi, S., Sasaya, H., Ikeuchi, T. and Nakayama, H. (2004) Protective effect of nicotine on tunicamycin-induced apoptosis of PC12 cells. Neuroscience Letters, 370, 244-247.
  9. Shimoke, K., Utsumi, T., Kishi, S., Nishimura, M., Sasaya, H., Kudo, M. and Ikeuchi, T. (2004) Prevention of endoplasmic reticulum stress-induced cell death by brain-derived neurotrophic factor in cultured cerebral cortical neurons. Brain Research, 1028, 105-111.
  10. Yamagishi, S., Matsumoto, T., Numakawa, T., Yokomaku, D., Adachi, N., Hatanaka, H., Yamada, M., Shimoke, K. and Ikeuchi, T. (2005) ERK1/2 are involved in low potassium-induced apoptotic signaling downstreem of ASK1-p38 MAPK pathway in cultured cerebellar granule neurons. Brain Research, 1038, 223-230.
  11. Shimoke, K., Kishi, S., Utsumi, T., Shimamura, Y., Sasaya, H., Oikawa, T., Uesato, S. and Ikeuchi, T. (2005) NGF-induced phosphatidylinositol 3-kinase signaling pathway prevents thapsigargin-triggered ER stress-mediated apoptosis in PC12 cells. Neuroscience Letters, 389, 124-128.
  12. Oikawa, T., Yamamoto, N., Shimoke, K., Uesato, S., Ikeuchi, T. and Fujioka, T. (2005) Purification, characterization, and overexpression of psychrophilic and thermolabile malate dehydrogenase of a novel antarctic psychrotorelant, Flavobacterium frigidimaris KUC-1. Bioscience, Biotechnology, and Biochemistry, 69, 2146-2154.
  13. Nakayama, H., Shimoke, K., Isosaki, M., Satoh, H., Yoshimizu, M. and Ikeuchi, T. (2006) Subtypes of neuronal nicotinic acetylcholine receptors involved in nicotine-induced phosphorylation of extracellular signal-regulated protein kinases in PC12h cells. Neuroscience Letters, 392, 101-104.
  14. Nagaoka, Y., Maeda, T., Kawai, Y., Nakashima, D., Oikawa, T., Shimoke, K., Ikeuchi, T., Kuwajima, H.,and Uesato, S. (2006) Synthesis and cancer antiproliferative activity of new histone deacetylase inhibitors: hydrophilic hydroxamates and 2-aminobenzamide-containing derivatives. European Journal of Medical Chemistry, 41, 697-708.
  15. Shimoke, K., Kudo, M. and Ikeuchi, T. (2007) Opposing mechanism of extracellular signal-regulated kinases on hydrogen peroxide-induced apoptosis in PC12 cells. The Journal of Tokyo Medical University, 65, 283-289.
  16. Kusunoki, T., Shimoke, K., Komatsubara, S., Kishi, S. and Ikeuchi, T. (2008) p-Nonylphenol induces endoplasmic reticulum stress-mediated apoptosis in neuronally differentiated PC12 cells. Neuroscience Letters, 431, 256-261.
  17. Sasaya, H., Utsumi, T., Shimoke, K., Nakayama, H., Matsumura, Y., Fukunaga, K. and Ikeuchi, T. (2008) Nicotine suppresses tunicamycin-induced, but not thapsigargin-induced, expression of GRP78 during ER stress-mediated apoptosis in PC12 cells. Journal of Biochemistry, 144, 251-257.
  18. Nakayama, H., Hamada, M., Fujikake, N., Nagai, Y., Zhao, J., Hatano, O., Shimoke, K., Isosaki, M., Yoshizumi, M. and Ikeuchi, T. (2008) ER stress is the initial response to polyglutamine toxicity in PC12 cells. Biochemical and Biophysical Research Communications, 377, 550-555.
  19. Shimoke, K., Yamazaki, I., Matsuki, Y., Ikeuchi, T. and Kudo, M. (2009) Caspase-3 activation and lipid peroxidation are important for apoptotic cell death in cerebral infarction. The Journal of Tokyo Medical University, 67, 15-21.
  20. Kishi, S., Shimoke, K., Nakatani, Y., Shimada, T., Okumura, N., Nagai, K., Shin-ya, K. and Ikeuchi, T. (2010) Nerve growth factor attenuates 2-deoxy-D-glucose-triggered endoplasmic reticulum stress-mediated apoptosis via enhanced expression of GRP78. Neuroscience Research, 66, 14-21.
  21. Maruoka, H., Sasaya, H., Shimamura, Y., Nakatani, Y., Shimoke, K. and Ikeuchi, T. (2010) Dibutyryl-cAMP up-regulates nur77 expression via histone modification during neurite outgrowth in PC12 cells. Journal of Biochemistry, 148, 93-101.
• 国際会議発表
  1. Shimoke, K., Amano, H., Nishimura, M., Utsumi, T., Kuromi, Y., Ikeuchi,T. NGF-mediated suppression of caspase-12 activation and apoptosis induced by ER stress in PC12 cells. 33rd Annual Meeting of Society for Neuroscience, New Olreans, U.S.A., 2003.
  2. Shimoke, K., Utsumi, T., Kishi, S., Sasaya, H. and Ikeuchi, T. (2004) Prevention of ER stress-induced cell death by BDNF in cultured cerebral cortical neurons. Society for Neuroscience Abstracts 30, 944.8.
  3. Shimoke, K., Yamamoto, Y., Kishi, S., Sasaya, H., Utsumi, T., Shimamura, Y., Shin-ya, K. and Ikeuchi, T. (2005) NGF prevents 2-deoxy-D-glucose-induced apoptosis in PC12 cells. Society for Neuroscience Abstracts 31, 337.8.
  4. Kishi, S., Shimoke, K., Sasaya, H., Shin-ya, K. and Ikeuchi, T. (2006) Nerve growth factor prevents ER stress-induced apoptosis in PC12 cells. IUBMB International Congress of Biochemistry and Molecular Biology Abstracts 20, 446.
  5. Hamada, M., Nakayama, H., Kishi, S., Nagai, Y., Shimoke, K. and Ikeuchi, T. (2006) Molecular mechanism of polyglutamine-expanded YFP-mediated ER stress in PC12 cell. IUBMB International Congress of Biochemistry and Molecular Biology Abstracts 20, 446.
  6. Nakayama, H., Utsumi, T., Shimoke, K., Sasaya, H., Shimamura, Y. and Ikeuchi, T. (2006) Nicotine protects tunicamycin-induced ER stress-mediated apoptosis in PC12 cells. IUBMB International Congress of Biochemistry and Molecular Biology Abstracts 20, 450.
  7. Shimoke, K., Komatsubara, S., Kishi, S., Hamade, M., Sasaya, H., Fujita, Y., and Ikeuchi, T. (2007) Involvement of up-regulated Bim expression in tunicamycin-induced ER stress-mediated apoptosis of PC12 cells. Society for Neuroscience Abstracts 33, 701.5.
  8. Shimoke, K., Kishi, S., Shimada T., Fujita, Y., Okumura, N. and Ikeuchi, T. (2008) Hyperinduction of GRP78 expression by NGF-TrkA signaling promotes cell survival during ER stress-mediated apoptosis of PC12 cell. Society for Neuroscience Abstracts 34, 355.9/BB4.
  9. Shimoke, K., Shimada, T., Kishi, S., Irifune, H., Nakatani, Y., Sasaya, H. and Ikeuchi, T. (2009) Nerve growth factor prevents ER stress-induced apoptosis via down-regulation of PUMA expression in PC12 cells. 17th ECDO Euroconference on Apoptosis Abstracts 28.
  10. Shimoke, K., Nakatani Y., Kishi, S., Shimada, T., Irifune, H., Sasaya, H. and Ikeuchi, T. (2009) Nerve growth factor enhances GRP78 expression only under the condition of ER stress in PC12 cells. Society for Neuroscience Abstracts 35, 153.7/M5.
• 学会発表
  1. 下家浩二、岸宗一郎、天野恭志、伊藤博公、内田仁司、工藤玄恵、池内俊彦: PC12細胞を用いたNGFによる小胞体ストレス抑制機構の解析、第75回日本生化学会、京都、2002年
  2. 天野恭志、下家浩二、伊藤博公、工藤玄恵、池内俊彦: NGFによる小胞体ストレス抑制機構、第25回日本分子生物学会、横浜、2002年
  3. 楠高志、岸宗一郎、内田仁司、下家浩二、池内俊彦: 分化PC12細胞を用いたp-Nonylphenolによる細胞死とNGFによる抑制機構の解析、第25回日本分子生物学会、横浜、2002年
  4. 下家浩二、天野恭志、西村学、内海孝宏、黒見靖、工藤玄恵、池内俊彦、NGF-mediated suppression of caspase-12 activation and apoptosis induced by ER stress in PC12 cells、第76回日本生化学会、横浜、2003年
  5. 下家浩二、中山均、岸宗一郎、内田仁司、池内俊彦、Protective effect of nicotine on tunicamycin-induced apoptosis of PC12 cells、第76回日本生化学会、横浜、2003年
  6. 西村学、内海孝宏、岸宗一郎、内田仁司、下家浩二、池内俊彦、PC12細胞を用いたtaurosodeoxycholic　acidによるtunicamycin誘 導小胞体ストレス抑制機構の解析、第26回日本分子生物学会、神戸、2003年
  7. 岡本直樹、内海孝宏、黒見靖、笹谷晴恵、下家浩二、池内俊彦、PC12細胞を用いた各種内分泌撹乱物質による細胞死誘導とNGFによる細胞死抑制機構の解析、第26回日本分子生物学会、神戸、2003年
  8. 中山　均、内海孝宏、下家浩二、池内俊彦、PC12細胞のツニカマイシン誘導アポトーシスに対するニコチン受容体を介した保護作用、日本薬理学会、2004年
  9. Shimoke, K., Utsumi, T., Kishi, S., Nishimura, M. and Ikeuchi, T. BDNF prevents ER stress-induced cell death in cultured cerebral cortical neurons. 第７7回日本生化学会発表抄録集, 76, 865 2004
  10. Sasaya, H., Kishi, S., Uchida, H., Shimoke, K. and Ikeuchi, T. (2004) Identification and characterization of signaling proteins which bind to the intracellular region of TrkA receptor using yeast two-hybrid system. 第７7回日本生化学会発表抄録集, 76, 865 2004
  11. 酒井祥太, 西村学, 岸宗一郎, 山本優子, 大西紀陽久, 笹谷晴恵, 下家浩二, 池内俊彦PC12細胞を用いた内分泌攪乱物質による小胞体ストレス誘導型細胞死とNGFによる細胞死抑制機構の解析 第２７回日本分子生物学会年会抄録集, 962 2004
  12. Nakayama, H., Shimoke, K., Nagai, Y., Isozaki, M., Satoh, H., Yoshizumi, M. and Ikeuchi, T. Relationship of polyglutamine-expanded GFP expression to ER stress in PC12 cells. 第４８回日本神経化学会抄録集, 192 2005
  13. Shimoke, K., Yamamoto, Y., Kishi, S., Sasaya, H., Utsumi, T., Shimamura, Y., Shin-ya, K. and Ikeuchi, T. NGF prevents 2-deoxy-D-glucose-induced apoptosis via PI3-K signaling pathway in PC12 cells. 第４８回日本神経化学会抄録集, 227 2005
  14. Yamamoto, Y., Shimoke, K., Kishi, S., Utsumi, T., Shin-ya, K. and Ikeuchi, T. Protective effect of NGF on 2-deoxy-D-glucose-induced apoptosis via PI3-K signaling pathway in PC12 cells. 第７８回日本生化学会発表抄録集, 77, 991 2005
  15. Shimamura, Y., Onishi, K., Maruoka, H., Sasaya, H., Maeda, D., Uesato, S., Shimoke, K. and Ikeuchi, T. Neurite outgrowth is induced by inhibitors of histone deacetylase in PC12 cells. 第７８回日本生化学会発表抄録集, 77, 991 2005
  16. Maruoka, H., Shimamura, Y., Sasaya, H., Kishi, S., Shimoke, K. and Ikeuchi, T. Epigenetic regulation of gene expression during neurite outgrowth by cAMP in PC12 cells. 第２８回日本分子生物学会年会抄録集, 218 2005
  17. Nakayama, H., Shimoke, K., Nagai, Y., Isozaki, M., Satoh, H., Yoshizumi, M. and Ikeuchi, T. Comparison of polyglutamine- , tunicamycin- and thapsigargin-induced ER stresses in PC12 cells. 第７９回日本薬理学会年会抄録集, 2006
  18. Shimoke, K., Kishi, S., Hamada, M., Sasaya, H., Fujita, Y. and Ikeuchi, T. (2007) Importance of up-regulated Bim expression during tunicamycin-induced ER stress-mediated apoptosis in PC12 cells. Bulletin of Japanese Society for Neurochemistry 46, 526.
  19. Nakayama, H., Hamada, M., Zhao, J., Shimoke, K., Isozaki, M., Satoh, H., Yoshizumi, M. and Ikeuchi, T. (2007) Effects of prorteasome inhibitors on tunicamycin-, thapsigargin-, and polyglutamine-induced ER stress and cell death in PC12 cells. Bulletin of Japanese Society for Neurochemistry 46, 527.
  20. Ando, K., Shimada, T., Kishi, S., Shimoke, K. and Ikeuchi, T. (2007) Analysis of endocrine disrupting chemical-induced ER stress-mediated apoptosis in PC12 cells. Congress of Biochemistry and Molecular Biology 2007 Abstracts 265.
  21. Kishi, S., Hamada, M., Fujita, Y., Shimoke, K., Shin-ya, K. and Ikeuchi, T. (2007) Nerve growth factor attenuates 2-deoxyglucose-triggered endoplasmic reticulum-mediated apoptosis via up-regulation of GRP78 expression. Congress of Biochemistry and Molecular Biology 2007 Abstracts 266.
  22. Sasaya, H., Utsumi, T., Shimoke, K.,Nakayama, H. and Ikeuchi, T. (2007) Nicotine suppresses tunicamycin-induced, but not thapsigargin-induced, expression of GRP78 during ER stress-mediated apoptosis in PC12 cells. Congress of Biochemistry and Molecular Biology 2007 Abstracts 266.
  23. Hamada, M., Shimoke, K., Kishi, S., Nagai, Y. and Ikeuchi, T. (2007) Polyglutamine-expanded protein-induced ER stress-mediated apoptosis and its suppression by NGF. Congress of Biochemistry and Molecular Biology 2007 Abstracts 445.
  24. Kishi, S., Shimoke, K., Okumura, N., Shimada, T., Fujita, Y., Nagai, K., Shin-ya, K. and Ikeuchi, T. (2008) Nerve growth factor attenuates 2-deoxyglucose-triggered endoplasmic reticulum-mediated apoptosis via enhanced induction of GRP78 expression. Bulletin of Japanese Society for Neurochemistry 47, 155.
  25. Sasaya, H., Shimoke, K., Kishi, S., Fijita, Y., Shimada, T., Nakayama, H. and Ikeuchi, T. (2008) Nicotine suppresses tunicamycin-induced expression during ER stress-mediated apoptosis via preventing a common step upstream of Ire1-XBP1 and ATF6 pathways in PC12 cells. Congress of Biochemistry and Molecular Biology 2008 Abstracts 238.
  26. Shimoke, K., Nakatani Y., Kishi, S., Shimada, T., Irifune, H., Sasaya, H. and Ikeuchi, T. (2009) Nerve growth factor promotes GRP78 expression only under the condition of ER stress. Bulletin of Japanese Society for Neurochemistry 48, 207.
  27. Nakatani, Y., Kishi, S., Shimoke, K., Shimada, T., Irifune, H., Sasaya, H. and Ikeuchi, T. (2009) Analysis of GRP78 promoter region involved in NGF-induced up-regulation during suppression of ER stress-mediated apoptosis in PC12 cells. Seikagaku 81, 3P-516.
  28. Shimada, T., Shimoke, K., Kishi, S., Irifune, H., Nakatani Y., Sasaya, H. and Ikeuchi, T. (2009) BAX oligomerization promotes ER stress-mediated apoptosis and nerve growth factor prevents it in PC12 cells. Japanese Society for Molecular Biology Abstracts 32, 2P-528.
• 総説・解説・紀要・その他
  1. 池内俊彦、下家浩二:　神経系細胞における細胞内情報伝達機構　-細胞死とその防御の機構-、第7回関西大学先端科学技術シンポジウム講演集、(2003)
  2. K. Shimoke, T. Ikeuchi Endoplasmic reticulum stress-mediated apoptosis and its prevention by neurotrophic factors. Proceedings of the Symposium of High Technology in Kansai University 9, 115-123 2005
  3. K. Shimoke, T. Ikeuchi Endoplasmic reticulum stress-induced apoptosis and its prevention by neurotrophins. New Trends in Brain Research, 61-74 2006
  4. Ikeuchi, T. and Shimoke, K. (2007) Prevention of endoplasmic reticulum stress and its induced apoptosis by nicotine and neurotrophins. Proceedings of the Symposium of High Technology in Kansai University 11, 109-116.
  5. Shimoke, K. and Ikeuchi, T. (2007) Endoplasmic reticulum stress-induced apoptosis and its preventive mechanism: Possible therapeutic strategy against neurodegenerative disorders. Engineering and Technolopgy, 14, 39-43.
  6. Ikeuchi, T. and Shimoke, K. (2008) Apoptosis inducing chemicals in the environment. Engineering and Technolopgy, 15, 69-76.

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